一、課程簡介:Nutrient-Gene Interaction Lecture Guideline

1. Introduce a nutrient metabolism and function
2. The function of genes
3. The function and metabolic pathways that the genes involved
4. Regulation mechanisms and research techniques
5. The structures of the genes-sequence structure and protein structure if available
6. Nutrient on gene expression
7. 展望

Approaches
1. 遇到的問題
2. 如何解決：研究的方法
3. 證明的結果
4. 得到的結論
5. 合理的推測：Implication
日期 預定課程進度 指定作業
2 月19 日 1. Opening remarks-A Big Picture: Metabolic pathway and regulation of FAS
2 月26 日 The power of life Involvement of NAD and FAD
3 月05 日 Metabolism and regulation : Glycolysis, TCA cycle, gluconeogenesis, and glycogen synthesis
3 月12 日 Lipid metabolism; Ketone body synthesis; AA metabolism
3 月19 日 Regulation mechanisms: allosteric modification, protein function and gene expression
3 月26 日 Gene structure and gene expression regulations: Prokaryote and eukaryote
4 月02 日 ***Midterm 1 The Big Picture due
4 月9 日 Glucose on gene expression;
Glucosamine on the expression of leptin
4 月16 日 Experimental Biology meeting; no class Going to San Diego
4 月23 日 The regulation of FAS expression by nutrients; Regulation of the expression of glucokinase Nutrient-gene interaction Chapter 1
4 月30 日 Fructose and glucosamine on gene expression
5 月07 日 Fatty acid and fat on gene expression
5 月14 日 Nutrient metabolism; Nutrients on adipocyte genes
5 月21 日 Vitamin A and gene expression
5 月28 日 Vitamin D and gene expression ;Vitamin E and Gene expression
6 月04 日 SPECIAL DELIVERY Your turn now!
6 月11 日 SPECIAL DELIVERY; last day of our class Your turn now!
6 月18 日 Conclusions and looking forward



二、先修課程:Genetics, Biochemistry

三、參考書目:參考文獻：
1. Lewin, B., 2000. Gene VII, Oxford University press.
2. Gibson, D.M. and R. A. Harris, 2002. Metabolic regulation in mammals. Taylor & Francis Inc. New York.
3. Moustaid-Moussa, N. and C. D. Berdanier, 2001. Nutrient-Gene interactions in health and disease. CRC Press. New York.
4. Annual Review of Nutrition 1993 to 2002.